Revascularization platelet-rich plasma

Wheaton cosmetic dentist Bryan Bauer


  1. Immature permanent tooth
  2. Side note=Avulsed tooth open apex to ~1-2mm
  3. Open apex to #80 without wall filing NaOCl and EDTA
  4. Final rinse with saline
  5. Dry paper points
  6. Triple antibiotic*
  7. Wait several weeks
  8. Evoke bleeding again with #80
  9. Blood clot
  10. MTA cap

*The use of the “3 mix-MP” triple antibiotic paste, developed by Hoshino and colleagues and consisting of ciprofloxacin, metronidazole, and minocycline, is effective for disinfection of the infected necrotic tooth, setting the conditions for subsequent revascularization (15, 16, 17, 18, 19) 1

  1. Hoshino E, Kurihara-Ando N, Sato I, et al. Invitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole, and minocycline. Int Endod J. 1996;29:125–130
  2. Sato T, Hoshino E, Uematsu H, Noda T. In vitro antimicrobial susceptibility to combinations of drugs on bacteria from carious and endodontic lesions of human deciduous teeth. Oral Microbiol Immunol. 1993;8:172–176
  3. Sato I, Ando-Kurihara N, Kota K, Iwaku M, Hoshino E. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole, and minocycline in situ. Int Endod J. 1996;29:118–124
  4. Takushige T, Cruz EV, Asgor Moral A, Hoshino E. Endodontic treatment of primary teeth using a combination of antibacterial drugs. Int Endod J. 2004;37:132–138
  5. Windley W, Teixeira F, Levin L, Sigurdsson A, Trope M. Disinfection of immature teeth with a triple antibiotic paste. J Endod. 2005;31:439–443


DPSCs and PRP no difference

PRP improved PA healing, apical closure, dentinal wall thickening BUT length same as without